Project (Melina Schuh)

Unraveling the Mysteries of Ovarian Development and Infertility

Introduction
Meiosis, the intricate process by which egg and sperm cells are formed, remains an enigma in many ways. Elucidating its complexities is not only of fundamental scientific interest but also holds profound medical implications. Aneuploidy, an error in chromosome segregation during meiosis, affects 10% to over 50% of human eggs depending on a woman's age. This chromosomal imbalance is the leading cause of pregnancy loss and age-related infertility.

Our Research Approach
To unravel the intricacies of ovarian development and infertility, we employ a combination of in vitro ovarian culture, sequencing techniques (including single-cell RNA-seq), proteomics and imaging. These powerful methods allow us to delve into the molecular and cellular mechanisms governing ovarian function and dysfunction.

Exciting Research Opportunities
Our lab offers a dynamic and stimulating environment for students eager to combine computational and experimental approaches to address fundamental questions in reproductive biology. We welcome highly motivated individuals with a background in bioinformatics, cell biology, or genetics to join our friendly, international, and multidisciplinary team.

Join Us and Make a Difference
By joining our team, you will have the opportunity to: